Nutrigenomics

Nutrigenomics: Personalised Nutrition Based on Your DNA

Nutrigenomics explores the powerful connection between nutrition and genetics. By understanding how your unique genetic variations influence nutrient metabolism and how nutrients impact gene expression, this cutting-edge science enables personalised dietary recommendations. With nutrigenomics, you can optimise your health, reduce disease risks, and tailor your nutrition strategy to align with your genetic makeup.

Pricing & Packages

Baseline Package – £400
Includes a DNA swab test, one panel of your choice (options listed below), a one-hour interpretation session, and written recommendations.

Additional Panels – £200 per panel
Additional panels can be purchased at the time of ordering or within three months. After three months, a new DNA swab will be required at an additional cost. Each additional panel includes interpretation and recommendations.

Any 5 Reports – £1000
Includes a DNA swab, five panels of your choice, an in-depth 60-90 minute interpretation session, and personalised written recommendations.

DNA Panels

Please choose from the following LifecodeGx Testing Panels:

Nutrient Core Report

This foundational test analyses how gene variants can affect food tolerance (and intolerance), appetite control and blood sugar balance, vitamin and mineral needs, detoxification ability, and susceptibility to inflammation and infection.

Genes included:

• Food Response: HLA-DQA1, HLA-DQB1 and LCT
• Caffeine: CYP1A2 and ADORA2A
• Microbiome: FUT2
• Vitamins: BCO1, MTHFR, FUT2, TCN2, SLC23A1, COL1A1, GC, VDR and VKORC1
• Blood Pressure: ACE and AG
• Detoxification: GSTM1
• Metabolism: FADS1/2, FTO, TCF7L2, PGC1A and LEPR
• Inflammation: TNF and IFNG
• Circadian Rhythm: CLOCK and PER1

Metabolics Report

Metabolism refers to all cellular chemical reactions and is essential for life. It can be divided into ‘anabolism’ (‘build up’ e.g synthesis of sugars, fats, proteins and nucleic acids) and catabolism (‘break down’ e.g., releasing energy in the form of ATP). These processes, and the balance between them, are the key to healthy energy metabolism and cellular function.

The Metabolics Report transforms our understanding of how genes confer metabolic individuality and underpin energy regulation, longevityand healthspan.�

Genes included:

• Appetite Regulation: BDNF, FAAH, FTO, LEPR, MC4R, NPY, POMC
• Nutrient Sensing: ADIPOQ, FOXO3, HIF1A, IRS1, PARP1, PGC1A, PPARA, PPARG, SIRT1, VEGFA
• Sugar Metabolism: AMPD1, GCK, GLUT2, IRS1, PPARG, TCF7L2
• Fat Metabolism: ADRB3, CD36, CPT1A, FABP2, LPL, PLIN1, PPARA, SREBF1
• Cholesterol and Bile: CYP7A1, HMGCR, LDLR, SREBF1
• Mitochondria and Inflammation: CAT, CRP, FOXO3, GPX1, IFNG, IL6, NRF2, SIRT3, SOD2, TNF, UCP1/2/3

Hormones Report

Steroid hormones are a group of hormones derived from cholesterol that act as chemical messengers in the body. They are involved in the regulation of many physiological processes in both men and women, such as the development and function of the reproductive system, metabolism, inflammation and immune system.

Genes included:

• Steroid Hormones: AKR1C4, CYP17A1, GABRA2, HSD11B1, SRD5A2, SULT2A1
• Oestrogen: COMT, CYP1A1, CYP1B1, CYP3A4, CYP19A1, ESR1, ESR2, MTHFR, NQO1
• Detoxification: ABCB1, GSTM1, GSTP1, SULT1A1, SULT1E1, UGT1A1
• HPA Axis: ADRB1, ADRB2, FKBP5, MTNR1B, OPRM1, TCF7L2
• HPG Axis: ESR1, ESR2, FAAH

Methylation Report

Methylation is the process of adding methyl groups, consisting of one carbon and three hydrogen atoms, to other molecules. It is involved in almost every metabolic process in the body, occurring billions of times every second in our cells and contributing to numerous crucial functions.

Imbalances in this process can increase susceptibility to chronic health conditions such as heart disease, circulatory problems, chronic fatigue, infertility, immune and autoimmune conditions, food and chemical sensitivities, and mood and psychiatric disorders, as well as cancer and premature ageing.

Genes included:

• Folate Cycle: DHFR, FOLH1, MTHFD1, MTHFR, RFC1, SHMT1 and TYMS
• Methionine Cycle: AHCY, BHMT, CHDH, FUT2, MAT1A, MTR, MTRR, PEMT and TCN2
• Neurotransmitter Cycle: COMT, MAOA, MAOB, MTHFR, PNMT, QDPR and VDR
• Transsulphuration Cycle: CBS, CTH, GSS, MUT and SUOX
• Urea Cycle: BDKRB2, NOS and SOD

Histamine Intolerance Report

Histamine has many functions: as a neurotransmitter, communicating messages to and from the brain and nervous system; triggering the release of stomach acid to help digestion; and it can also be released after stress, injury or allergic reaction as part of the body’s immune response.

Genes included:

• Nervous, Immune: HNMT, MAOB and NAT2
• Methylation: MTHFR
• Gastro Intestinal: ALDH2, DAO and GPX1

Oestrogen Balance Report

Oestrogen is one of the two major female steroidal sex hormones, the other being progesterone. Men also require oestrogen for producing sperm and maintaining libido, but at significantly lower levels. Oestrogen main role is to increase the growth and production of cells. It is responsible for the development of the female reproductive system and is also involved in maintaining bone density, blood clotting and affects hair, skin, mucous membranes and pelvic muscles.

Genes included:

• Synthesis: CYP17A1, CYP19A1 and SULT2A1
• Activation: CYP1A1, CYP1B1 and CYP3A4
• Receptors: ESR1 and ESR2
• Methylation: COMT and MTHFR
• Metabolism: GSTM1, GSTP1, SULT1A1, SULT1E1 and UGT1A1

Detoxification Report

Detoxification is the physiological removal of toxic substances from the human body. It is mainly carried out by the liver, and to a lesser extent the small intestine, kidneys and lungs. Substances such as nutrients, food additives, pesticides, medications, air pollutants, alcohol and hormones are transformed from being fat-soluble to water-soluble, allowing them to be more easily excreted from the body. The process occurs in two major phases: Phase I primes toxic molecules for deactivation and Phase II finishes the deactivation and prepares for elimination.

Genes included:

• CYP450s: CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4
• Alcohol: ADH1B, ADH1C and ALDH2
• Pesticides: PON1
• ROS: SOD2, GPX1 and NQO1
• Glucuronidation: UGT1A1, UGT1A6
• Methylation: COMT and TPMT
• Sulphonation: SULT1A1, SULT1E1 and SULT2A1
• Acetylation: NAT1 and NAT2
• Glutathione: GSTM1, GSTP1 and GSTT1
• Antiporter: ABCB1

Nervous System Report

The nervous system supports the transmission of messages around the mind and body, enabling an individual to respond to their environment. A neurotransmitter is a molecule that carries signals between neurons and across nerve junctions (synapses). Excitatory neurotransmitters increase the likelihood a neuron will fire a signal, while inhibitory neurotransmitters have the opposite effect. In order for us to interact effectively with our environment these must remain in balance.

Genes included:

• Serotonin: ALDH2, HTR1A, HTR2A, MAOA, MTHFR, SLC18A1 (VMAT), VDR and TPH1 &2
• Kynurenic Acid: FKBP5, IFNG and TNF
• Melatonin: ASMT and MTNR1B
• Dopamine: ALDH2, COMT, DRD2, MAOB, MAOA, MTHFR, OPRM1, SLC6A3 (DAT), TH and VDR
• Adrenergic: ADRB2, COMT, DBH, MAOA, PNMT, SLC6A2 (NET) and SLC18A1 (VMAT)
• GABA: ALPL, GAD1, GAD2 and GABRA2
• Cannabinoid: CNR1, TRPV1 and FAAH

APOE Report

The Apolipoprotein E (APOE) gene is best known for its role in lipid (fat) metabolism by helping to remove cholesterol from the bloodstream. It can exist in three main forms known as E2, E3 and E4.

Genes included:

• Lipid Metabolism: APOE
• Methylation: MTHFR
• Inflammation: IFNG and TNF
• Detoxification: GSTM1, GSTT1 and GSTP1
• Neuroprotection: BDNF

Thyroid Balance Report

The thyroid is an endocrine gland in the neck that produces two thyroid hormones – triiodothyronine (T3) and thyroxine (T4), and calcitonin. Thyroid hormones control the metabolism of almost every cell in the body, with wide-ranging metabolic, developmental and cardiovascular effects.

Genes included:

• HPT Axis: CAPZB, FKBP5, GPX1*, PDE8B, TG*, TSHR* (*also involved in autoimmunity)
• Autoimmune: CTLA4, FOXE1, HLA-DQA1, HLA-DQB1 and PTPN22
• Inflammation: CD40, FCRL3, IL6, TNF, GC and VDR
• Transport: SLCO1B1 and SLCO1C1
• Activation: DIO1, DIO2, BCO1, GC and VDR
• Metabolism: SULT1A1, SULT1E1, UGT1A1

Athlete Report

DNA sequencing has opened the door to personalised approaches to health and fitness, enabling a more intelligent approach to training, recovery and performance. In this report, we present elements of your unique DNA profile that have been shown to affect athletic performance.

Genes included:

• Balance: HTR2A, LCT, HLA-DQA1
• Cardio: ACE, AGT, BDKRB2, NOS3, VEGFA
• Fuel: MTHFR, MTRR, ADRB2, AMPD1, PGC1A, PPARA
• Inflammation: IL6, TNF
• Motivate: ADRB2, ADORA2A, CYP1A2
• Oxidative Stress: GSS, NOS3, SOD2
• Sleep: CLOCK, PER1
• Structure: ACTN3, COL1A1, VDR, VKORC1

All of the Lifecode Gx reports include:

• personalised, colour coded genotype results
• gene function and SNP impact descriptions
• links to research evidence
• clinically relevant SNPs
• nutrient and other epigenetic impacts